mitoClone2
This package primarily identifies variants in mitochondrial genomes from BAM alignment files. It filters these variants to remove RNA editing events then estimates their evolutionary relationship (i.e. their phylogenetic tree) and groups single cells into clones. It also visualizes the mutations and providing additional genomic context.
README
mitoClone2 The R package is used for performing the analysis of clonal heterogeneity based on nuclear and mitochondrial mutations in single cell RNA or DNA sequencing. You can read about the package and explore an extensive vignette in the supplemental section of our accompanying publication: Story B, Velten L, Mönke G, Annan A, Steinmetz L. Mitoclone2: an R package for elucidating clonal structure in single-cell RNA-sequencing data using mitochondrial variants. NAR Genomics and Bioinformatics.…
- Repository
- github.com/benstory/mitoclone2
Source attribution
- GitHub — github.com/benstory/mitoclone2
- Bioconductor — mitoClone2
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